Which cocktail necessitates the use of both lime juice and simple sugars?

The cocktail that requires both lime juice and simple sugars is a Moscow Mule. This refreshing drink is traditionally made with vodka, ginger beer, and lime juice, and it often includes a sweetening component, which can come from simple syrup or other sweeteners to balance the tartness of the lime juice. The lime juice provides acidity and brightness, while the simple sugars help to create a smooth, rounded flavor profile in the cocktail.

In contrast, other cocktails listed do not use both of these ingredients in their standard recipes. A Negroni, for example, is made with equal parts of gin, vermouth, and Campari, producing a bitter and herbal flavor without the need for lime juice or sugar. The Old Fashioned is a whiskey-based cocktail that typically incorporates sugar but is often paired with bitters and does not use lime juice. The Whiskey Sour, while it does use citrus, often employs lemon juice instead of lime juice, along with simple syrup, making it distinct from the Moscow Mule.